Journal
SOFT MATTER
Volume 5, Issue 20, Pages 3984-3991Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b821583a
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Funding
- Groupe de Recherche Universitaire de l'Universite de Montreal
- Natural Sciences and Engineering Research Council of Canada
- E. A. Baker Foundation
- Canadian Institutes of Health Research (CIHR)
- CONACYT
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Uptake and intracellular trafficking of hydrogel nanoparticles (NPs) of N,N-diethyl acrylamide and 2-hydroxyethyl methacrylate crosslinked with N,N'-methylene-bis-acrylamide were studied with a RAW 264.7 murine macrophage cell line. Results show that the uptake rate, the mechanism of internalization and the concentration of internalized NPs are correlated to the NP Young modulus. Soft NPs are found to be internalized preferentially via macropinocytosis while the uptake of stiff NPs is mediated by a clathrin-dependent mechanism. NPs with an intermediate Young modulus exhibit multiple uptake mechanisms. The accumulation rate of the NPs into lysosomal compartments of the cell is also dependent on the NP elasticity. Our results suggest that control over the mechanical properties of hydrogel NPs can be used to tailor the cellular uptake mechanism and kinetics of drug delivery.
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