Journal
SOFT MATTER
Volume 5, Issue 3, Pages 529-532Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b815884c
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan [18810009, 19031003]
- Japan Science and Technology Agency
- Inoue Foundation for Science
- Kao Foundation for Arts and Sciences
- Japan Society for the Promotion of Science
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The acidic pH-sensitivity of polyion complex vesicles (PICsomes) was investigated, using dynamic light scattering (DLS) and confocal laser scanning microscopy (CLSM). PICsomes showed pH-dependent and reversible structural transition, and also underwent a change in permeability by sensing acidic pH. Increased membrane permeability at the pH corresponding to cellular endosomes may be useful for future applications of PICsomes as a delivery vehicle of biologically active compounds to intracellular compartment.
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