Journal
SOFT MATTER
Volume 5, Issue 5, Pages 962-965Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b818906d
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Funding
- NSRRC [2007-1-018-2]
- National Science Council [NSC 96-2120-M-007-004]
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A pH-responsive hydrogel targeted for various biomedical applications has been developed using a naturally-abundant biopolymer, chitosan, with controlled grafting of hydrophobic side chains. The rapid hydrogelation is driven by a transformation of the nanostructure of the side-chain aggregates from local micelles to interconnected nanodomains in a sponge phase due to the dominance of hydrophobic interaction near physiological pH.
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