4.6 Article

Tumor microvasculature targeting with dendrimer-entrapped gold nanoparticles

Journal

SOFT MATTER
Volume 4, Issue 11, Pages 2160-2163

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b810885d

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Funding

  1. NATIONAL CANCER INSTITUTE [P50CA069568] Funding Source: NIH RePORTER
  2. NCI NIH HHS [P50 CA069568-05, P50 CA069568] Funding Source: Medline

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Monodisperse dendrimer-entrapped gold nanoparticles (diameter 3.0 nm) were prepared using G5 poly(amidoamine) (PAMAM) dendrimer functionalized with fluorescein isothiocyanate (FI) and Arg-Gly-Asp (RGD) peptide as template; in vitro targeting efficacy to integrin receptor expressing cells was confirmed by flow cytometry, confocal microscopy, and ICP-MS.

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