Journal
SOFT MATERIALS
Volume 8, Issue 2, Pages 130-148Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15394451003756282
Keywords
Boric acid; Hydrogels; Swelling; Viscoelastic properties; Wound dressing
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Funding
- Ministry of Education, Youth and Sports of the Czech Republic [MSM 70088352101]
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The medicated hydrogels were prepared aseptically under moist heat treatment using polyvinylpyrrolidone (PVP), sodium-carboxymethylcellulose (CMC), polyethyleneglycol (PEG), agar, glycerin and/or boric acid (BA) and designated as PVP-CMC and PVP-CMC-BA. The aim of this study was to develop some medicinal values-based hydrogels. BA was used to build up the medicinal values (antiseptic and antimicrobial properties) within the hydrogels. Optical images, scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy of the hydrogels indicated that boric acid is uniformly dispersed within the cross-linked hydrogel network that may heal and protect the wounds from infections/sepsis. Swelling study in presence of water and physiological saline solution confirmed its reasonable absorption capacity. The rheological properties and mechanical properties demonstrated that the boric acid incorporated hydrogels are quite flexible. Assessment of antimicrobial property study proves that PVP-CMC-BA (3% BA) has strong infection protection capacity.
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