Journal
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
Volume 9, Issue 10, Pages 1589-1600Publisher
OXFORD UNIV PRESS
DOI: 10.1093/scan/nst156
Keywords
autism spectrum disorders; superior temporal sulcus; functional connectivity; functional magnetic resonance imaging; emotion recognition
Categories
Funding
- Flanders Fund for Scientific Research (FWO) [0749.09]
- IAP from the Interuniversity Attraction Poles program of the Belgian federal government [P7/21]
- Research Council of the University of Leuven [IDO/08/013]
- FWO
- Flanders Fund for Scientific Research [G.0404.12/G.0758.10]
- Olin, Institute of Living at Hartford Hospital [Autism Speaks], Hartford Hospital
- Oregon Health and Science University [R00 MH091238, R01 MH096773, R01 MH086654]
- Oregon Health and Science University [Simon Foundation, Inc.]
- Trinity Centre for Health Sciences [The Meath Foundation, Adelaide]
- Trinity Centre for Health Sciences [Meath Hospital]
- Trinity Centre for Health Sciences [National Children's Hospital (AMNCH), Tallaght]
- Trinity Centre for Health Sciences [Kyulan Family Foundation]
- University of Utah, School of Medicine [National Institutes of Health] [K08 MH092697, RO1MH080826, P50MH60450, T32DC008553, R01NS34783]
- Autism Speaks Mentor-based Predoctoral Fellowship [1677]
- University of Utah Multidisciplinary Research Seed Grant
- NRSA Predoctoral Fellowship [F31 DC010143]
- Ben B. and Iris M. Margolis Foundation
- Yale Child Study Center [Simons Foundation]
- Yale Child Study Center [Autism Speaks]
- Yale Child Study Center [John Merck Scholars Fund]
- Yale Child Study Center [Autism Science Foundation]
- Yale Child Study Center [NICHD]
- Yale Child Study Center [NIMH]
- University of Leuven [G. 0354.06, 6/29]
- University of Leuven [KU Leuven Research Council] [IDO/08/013]
- NYU Langone Medical Center [NIH] [K23MH087770, R21MH084126, R01MH081218, R01HD065282]
- NYU Langone Medical Center [Autism Speaks]
- NYU Langone Medical Center [Stavros Niarchos Foundation]
- NYU Langone Medical Center [Leon Levy Foundation]
- University of California, Los Angeles: Sample 1 (UCLA Autism Center of Excellence)
- University of California, Los Angeles: Sample 1 (NICHD) [P50 HD055784]
- University of California, Los Angeles: Sample 1 (NIMH) [1R01 HD065280-01]
- University of Michigan [Autism Speaks]
- University of Michigan [NIH] [U19 HD035482, MH066496]
- Autism Speaks Pre-doctoral Fellowship [4773]
- Michigan Institute for Clinical and Health Research (MICHR) Pre-doctoral Fellowship [UL1RR024986]
- NIH [R21 MH079871]
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Neurodevelopmental disconnections have been assumed to cause behavioral alterations in autism spectrum disorders (ASDs). Here, we combined measurements of intrinsic functional connectivity (iFC) from resting-state functional magnetic resonance imaging (fMRI) with task-based fMRI to explore whether altered activity and/or iFC of the right posterior superior temporal sulcus (pSTS) mediates deficits in emotion recognition in ASD. Fifteen adults with ASD and 15 matched-controls underwent resting-state and task-based fMRI, during which participants discriminated emotional states from point light displays (PLDs). Intrinsic FC of the right pSTS was further examined using 584 (278 ASD/306 controls) resting-state data of the Autism Brain Imaging Data Exchange (ABIDE). Participants with ASD were less accurate than controls in recognizing emotional states from PLDs. Analyses revealed pronounced ASD-related reductions both in task-based activity and resting-state iFC of the right pSTS with fronto-parietal areas typically encompassing the action observation network (AON). Notably, pSTS-hypo-activity was related to pSTS-hypo-connectivity, and both measures were predictive of emotion recognition performance with each measure explaining a unique part of the variance. Analyses with the large independent ABIDE dataset replicated reductions in pSTS-iFC to fronto-parietal regions. These findings provide novel evidence that pSTS hypo-activity and hypo-connectivity with the fronto-parietal AON are linked to the social deficits characteristic of ASD.
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