Journal
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
Volume 3, Issue 2, Pages 135-143Publisher
OXFORD UNIV PRESS
DOI: 10.1093/scan/nsn007
Keywords
emotion; autism; prefrontal; effective connectivity; fMRI
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Several recent studies suggest that autism may result from abnormal communication between brain regions. We directly assessed this hypothesis by testing the presence of abnormalities in a model of the functional cerebral network engaged during explicit emotion processing in adults with high functioning autism or Asperger syndrome. Comparison of structural equation models revealed abnormal patterns of effective connectivity, with the prefrontal cortex as a key site of dysfunction. These findings provide evidence that abnormal long-range connectivity between structures of the 'social brain' could explain the socio-emotional troubles that characterize the autistic pathology.
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