Journal
SMALL
Volume 11, Issue 9-10, Pages 1055-1071Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201401943
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Funding
- National Natural Science Foundation of China [91027040, 31061160496]
- National Basic Research Program of China [2012CB821500]
- Scientific Research Foundation of Graduate School of Nanjing University [2013CL01]
- College Postgraduate Research and Innovation Project of Jiangsu province [CXZZ13_0036]
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With the rapid development of nanotechnology, nanoparticles have been widely used in many applications such as phototherapy, cell imaging, and drug/gene delivery. A better understanding of how nanoparticles interact with bio-system (especially cells) is of great importance for their potential biomedical applications. In this review, the current status and perspective of theoretical and computational investigations is presented on the nanoparticle-biomembrane interactions in cellular delivery. In particular, the determining parameters (including the properties of nanoparticles, cell membranes and environments) that govern the cellular uptake of nanoparticles (direct penetration and endocytosis) are discussed. Further, some special attention is paid to their interactions beyond the translocation of nanoparticles across membranes (e. g., nanoparticles escaping from endosome and entering into nucleus). Finally, a summary is given, and the challenging problems of this field in the future are identified.
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