Journal
SMALL
Volume 10, Issue 18, Pages 3783-3794Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201302880
Keywords
biomaterials; bioinspired materials; structure-property relationships; polymers; polylactide; stereocomplex; pH neutralization; inflammation
Categories
Funding
- Cell Regeneration Program [2012M3A9C6049717]
- National Research Foundation (NRF) (MSIP) through the National Research Foundation of Korea - the Ministry of Science, ICT & Future Planning (MSIP) [2013034945]
- Industrial Strategic Technology Development Program - Ministry of Trade, Industry and Energy (MOTIE) [10043971]
- KIST Program - MSIP, Korea [2E23720]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10043971, 10048019] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Council of Science & Technology (NST), Republic of Korea [2E24680] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2012M3A9C6049717, 2008-2000033, 2010-0017825] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Biodegradable polymers such as poly(l-lactide) (PLLA) have been widely utilized as materials for biomedical applications. However, the relatively poor mechanical properties of PLLA and its acid-induced cell inflammation brought about by the acidic byproducts during biodegradation pose severe problems. In this study, these drawbacks of PLLA are addressed using a stereocomplex structure, where oligo-d-lactide-grafted magnesium hydroxide (MgO-ODLA) is synthesized by grafting d-lactide onto the surface of magnesium hydroxide, which is then blended with a PLLA film. The structure, morphology, pH change, thermal and mechanical properties, in-vitro cytotoxicity, and inflammation effect of the MgO-ODLAs and their PLLA composites are evaluated through various analyses. The PLLA/MgO70-ODLA30 (0-20 wt%) composite with a stereocomplex structure shows a 20% increase in its tensile strength and an improvement in the modulus compared to its oligo-l-lactide (PLLA/MgO70-OLLA30) counterpart. The interfacial interaction parameter of PLLA/MgO70-ODLA30 (5.459) has superior properties to those of PLLA/MgO70-OLLA30 (4.013) and PLLA/Mg(OH)(2) (1.774). The cell cytotoxicity and acid-induced inflammatory response are suppressed by the neutralizing effect of the MgO-ODLAs. In addition, the inflammatory problem caused by the rapid acidification of the stereocomplex structure is also addressed. As a result, the stereocomplex structure of the MgO-ODLA/PLLA composite can be used to overcome the problems associated with the biomedical applications of PLLA films.
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