Journal
SMALL
Volume 10, Issue 9, Pages 1799-1804Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201303329
Keywords
phototriggered release; caged drug; gold nanoparticle; photodynamic therapy
Categories
Funding
- Case Western Reserve University
- National Institute of Biomedical Imaging and Bioengineering [5R01EB012099]
Ask authors/readers for more resources
A photoprecursor Pc 227 is covalently bound onto gold nanoparticles (Au NPs) to produce the known photodynamic therapy (PDT) drug Pc 4 upon 660 nm photoirradiation. The photochemical formation of the photoproduct Pc 4 is identified by spectroscopy, chromatography, and mass spectrometry and its PDT efficacy is equal to Pc 4 when administered non-covalently by Au NPs, with the added benefit of improved covalent delivery and targeted NIR-triggered release from the covalent Pc 227-Au NP conjugate, while during transport the attached Pc 227 is quenched by the Au NP and PDT inactivated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
