Journal
SMALL
Volume 10, Issue 24, Pages 5068-5076Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201401538
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Funding
- Australian Research Council
- Queensland Government
- Australian National Fabrication Facility at the Centre for Microscopy and Microanalysis, The University of Queensland
- Australian Microscopy and Microanalysis Research Facility at the Centre for Microscopy and Microanalysis, The University of Queensland
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A rationally designed two-step synthesis of silica vesicles is developed with the formation of vesicular structure in the first step and fine control over the entrance size by tuning the temperature in the second step. The silica vesicles have a uniform size of approximate to 50 nm with excellent cellular uptake performance. When the entrance size is equal to the wall thickness, silica vesicles after hydrophobic modification show the highest loading amount (563 mg/g) towards Ribonuclease A with a sustained release behavior. Consequently, the silica vesicles are excellent nano-carriers for cellular delivery applications of therapeutical biomolecules.
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