Journal
SMALL
Volume 9, Issue 21, Pages 3678-3684Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201202155
Keywords
aptamer; gold nanorods; photosensitizer; multimodal therapy
Categories
Funding
- China Scholarship Council (CSC)
- Southwest University [SWU112092]
- National Institutes of Health [GM079359, CA133086]
- National Key Scientific Program of China [2011CB911000]
- NSFC [21221003]
- China National Instrumentation Program [2011YQ03012412]
- National Natural Science Foundation of China [21035005]
- China NSFC [20805038]
- China National Grand Program on Key Infectious Disease [2009ZX10004-312]
- Key Project of Natural Science Foundation of China [90606003]
- International Science & Technology Cooperation Program of China [2010DFB30300]
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In this work, a DNA inter-strand replacement strategy for therapeutic activity is successfully designed for multimodal therapy. In this multimodal therapy, chlorin e6 (Ce6) photosensitizer molecules are used for photodynamic therapy (PDT), while aptamer-AuNRs, are used for selective binding to target cancer cells and for photothermal therapy (PTT) with near infrared laser irradiation. Aptamer Sgc8, which specifically targets leukemia T cells, is conjugated to an AuNR by a thiol-Au covalent bond and then hybridized with a Ce6-labeled photosensitizer/reporter to form a DNA double helix. When target cancer cells are absent, Ce6 is quenched and shows no PDT effect. However, when target cancer cells are present, the aptamer changes structure to release Ce6 to produce singlet oxygen for PDT upon light irradiation. Importantly, by combining photosensitizer and photothermal agents, PTT/PDT dual therapy supplies a more effective therapeutic outcome than either therapeutic modality alone.
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