Journal
SMALL
Volume 10, Issue 5, Pages 980-988Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201302312
Keywords
DNA; intercalators; controlled release; logic gates; codelivery
Categories
Funding
- National Natural Science Foundation of China [21273112]
- Natural Science Foundation of Jiangsu Province [BK2012719]
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Novel DNA-gated mesoporous silica nanoparticle (MSN) vehicles functionalized with disulfide-linked acridinamine intercalators are constructed for multi-responsive controlled release. The DNA-gated MSN vehicles release cargo encapsulated in the MSN pores under different stimuli, including disulfide reducing agents, elevated temperature, and deoxyribonuclease I (DNase I), for codelivery of drugs and DNA/genes in different forms. Furthermore, the cascade release of encapsulated and intercalative drugs is controlled by AND logic gates in combination of dual stimuli. The ingeniously designed DNA-gated MSN vehicles integrates multiple responses and AND logic gate operations into a single smart nanodevice not only for codelivery of drugs and DNA/genes but also for cascade release of two drugs and has promising biological applications to meet diverse requirements of controlled release.
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