Journal
SMALL
Volume 9, Issue 16, Pages 2793-2800Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201201916
Keywords
photodynamic therapy; DNA; drug delivery; mesoporous materials; nanoparticles
Categories
Funding
- National Basic Research Program of China [2012CB720602, 2011CB936004]
- National Natural Science Foundation of China [20831003, 21210002, 91213302, 20833006, 21072182, 90913007]
Ask authors/readers for more resources
A novel light-operated vehicle for targeted intracellular drug delivery is constructed using photosensitizer-incorporated G-quadruplex DNA-capped mesoporous silica nanoparticles. Upon light irradiation, the photosensitizer generates ROS, causing the DNA capping to be cleaved and allowing cargo to be released. Importantly, this platform makes it possible to develop a drug-carrier system for the synergistic combination of chemotherapy and PDT for cancer treatment with spatial/temporal control. Furthermore, the introducing of targeting ligands further improves tumor targeting efficiency. The excellent biocompatibility, cell-specific intracellular drug delivery, and cellular uptake properties set up the basis for future biomedical application that require in vivo controlled, targeted drug delivery.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available