Journal
SMALL
Volume 9, Issue 9-10, Pages 1595-1607Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201201962
Keywords
engineered nanomaterials; inflammasomes; inflammation; nanotoxicology; NLRP3
Categories
Funding
- US Public Health Service (UCLA Center for NanoBiology and Predictive Toxicology) [U19 ES019528]
- National Science Foundation
- Environmental Protection Agency [DBI 0830117]
- [RC2 ES018766]
- [RO1 CA133697]
- [RO1 ES016746]
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Engineered nanomaterials (ENMs) continue to attract significant attention because they have novel physicochemical properties that can improve the functions of products that will benefit human lives. However, the physicochemical properties that make ENMs attractive could interact with biological systems and induce cascades of events that cause toxicological effects. Recently, there have been more studies suggesting inflammasome activation may play an important role in ENM-induced biological responses. Inflammasomes are a family of multiprotein complexes that are increasingly recognized as major mediators of the host immune system. Among these, NLRP3 inflammasome is the most studied that could directly interact with ENMs to generate inflammatory responses. In this review, the ENM physicochemical properties are linked to NLRP3 inflammasome activation. An understanding of the mechanisms of ENMNLRP3 inflammasome interactions will provide us with strategies for safer nanomaterial design and therapy.
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