Journal
SMALL
Volume 9, Issue 9-10, Pages 1521-1532Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201201390
Keywords
nanoparticles; circulation; internalization; physicochemical characteristics; tumor therapy
Categories
Funding
- National Basic Research Program of China [2010CB934000, 2012CB932502, 2009CB930304]
- National Natural Science Foundation of China [30925041]
- Shanghai Elitist Program [11XD1406200]
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Nanoparticles have many potential applications in tumor therapy. Systemically administered nanoparticles should remain in circulation for a long time to increase their accumulation in targeted tissues before being cleared by the reticuloendothelial system, and be effectively internalized by the targeted cells, which can be influenced significantly by the physicochemical characteristics of nanoparticles, such as particle size, surface properties, and particle shape. This review highlights the impact of the main affects of physicochemical properties on nanoparticle transport behavior in blood, their uptake and clearance by macrophages and their consequent biodistribution, as well as their interaction with targeted cells.
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