Journal
SMALL
Volume 9, Issue 1, Pages 81-89Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201201098
Keywords
biomaterials; cells; mechanosensitivity; microfabrication; nanotopography
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Funding
- National Science Foundation [CMMI 1129611]
- Department of Mechanical Engineering at the University of Michigan, Ann Arbor
- Directorate For Engineering [1149401] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys [1149401] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1129611] Funding Source: National Science Foundation
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Cells exhibit high sensitivity and diverse responses to the intrinsic nanotopography of the extracellular matrix through their nanoscale cellular sensing machinery. A simple microfabrication method for precise control and spatial patterning of the local nanoroughness on glass surfaces by using photolithography and reactive ion etching is reported. It is demonstrated that local nanoroughness as a biophysical cue could regulate a diverse array of NIH/3T3 fibroblast behaviors, including cell morphology, adhesion, proliferation, migration, and cytoskeleton contractility. The capability to control and further predict cellular responses to nanoroughness might suggest novel methods for developing biomaterials mimicking nanotopographic structures in vivo for functional tissue engineering.
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