Journal
SMALL
Volume 9, Issue 1, Pages 9-21Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201200996
Keywords
microfluidics; cells; diagnostics; patterning; screening
Categories
Funding
- National Science Foundation of China [90813032, 20890020, 31170905]
- Ministry of Science and Technology [2009CB930001, 2011CB933201]
- Chinese Academy of Sciences [KJCX2-YW-M15]
- K. C. Wong Education Foundation
- China Postdoctoral Science Foundation [20100480246]
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Microfluidics, a toolbox comprising methods for precise manipulation of fluids at small length scales (micrometers to millimeters), has become useful for manipulating cells. Its uses range from dynamic management of cellular interactions to high-throughput screening of cells, and to precise analysis of chemical contents in single cells. Microfluidics demonstrates a completely new perspective and an excellent practical way to manipulate cells for solving various needs in biology and medicine. This review introduces and comments on recent achievements and challenges of using microfluidics to manipulate and analyze cells. It is believed that microfluidics will assume an even greater role in the mechanistic understanding of cell biology and, eventually, in clinical applications.
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