Journal
SMALL
Volume 8, Issue 11, Pages 1693-1700Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201102263
Keywords
drug delivery; fluorescence; nanoparticles; photochemistry; polymers
Categories
Funding
- NSF MRSEC through the Princeton Center for Complex Materials [DMR-0819860]
- American Chemical Society [PRF 49903-DNI10]
- 3M
- NIH [GM083997, HL110335]
- Susan G. Komen for the Cure [FAS0703855]
- David and Lucile Packard Foundation
- Alfred P. Sloan Foundation
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The ability to create aqueous suspended stable nanoparticles of the hydrophobic homopolymer poly(?-caprolactone) end-functionalized with coumarin moieties (CPCL) is demonstrated. Nanoparticles of CPCL are prepared in a continuous manner using nanoprecipitation. The resulting nanoparticles are spherical in morphology, about 40 nm in diameter, and possess a narrow size distribution and excellent stability over 4 months by repulsive surface charge. Nanoparticle size can be easily controlled by manipulating the concentration of CPCL in the solution. The interparticle assembly between the nanoparticles can be reversibly adjusted with photoirradiation due to photoinduced [2 + 2] cyclodimerization and cleavage between the coumarin molecules. In addition, the CPCL nanoparticles show significant cellular uptake without cytotoxicity, and the intrinsic fluorescence of the coumarin functional group permits the direct detection of cellular internalization.
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