Journal
SMALL
Volume 9, Issue 9-10, Pages 1786-1798Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201201388
Keywords
carbon nanotubes; neuronal differentiation; PC12; growth factors; signaling pathways
Categories
Funding
- Ministry of Science and Technology of China [2011CB933401, 2012CB934003]
- National Natural Science Foundation of China [10975040]
- National Major Scientific Instruments Development Project [2011YQ03013406]
- NIH [R15 ES021079-01]
- Danish Agency for Science Technology and Innovation [09-067185]
- European Commission through the Seventh Framework Programme for Research and Technological Development [263215]
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Numerous unique properties of carbon nanotubes make them attractive for applications in neurobiology such as drug delivery, tissue regeneration, and as scaffolds for neuronal growth. In this study, the critical roles of the length of multiwall carbon nanotubes (MWCNTs) on a neuronal-like model cell line PC12 cells are investiaged. Incubation of PC12 cells with carboxylated MWCNTs did not significantly affect cellular morphology and viability at lower concentrations. Short MWCNTs show higher cellular uptake and more obvious removal compared to longer ones, which can result in higher ability to promote PC12 cell differentiation. Pre-incubation of short MWCNTs can up-regulate the expression of neurotrophin signaling pathway-associated TrkA/p75 receptors and Pincher/Gap43/TH proteins, which might be the underlying mechanism for the improved differentiation in PC12 cells. The current results provide insight for future applications of MWCNTs in neuron drug delivery and neurodegenerative disease treatment.
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