Journal
SMALL
Volume 8, Issue 20, Pages 3143-3150Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201200783
Keywords
nanoparticle; transdermal; drug delivery; near-infrared laser; photothermal ablation
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Funding
- National Center for Research Resources
- National Institutes of Health (RI-INBRE Award) [P20RR016457-10]
- Rhode Island Foundation Medical Research Grant
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A photothermal ablation-enhanced transdermal drug delivery methodology is developed based on hollow copper sulfide nanoparticles (HCuSNPs) with intense photothermal coupling effects. Application of nanosecond-pulsed near-infrared laser allows rapid heating of the nanoparticles and instantaneous heat conduction. This provides very short periods of time but extremely high temperatures in local regions, with focused thermal ablation of the stratum corneum. The depth of skin perforations can be controlled by adjusting the laser power. Skin disruption by HCuSNP-mediated photothermal ablation significantly increases the permeability of human growth hormone. This technique offers compelling opportunities for macromolecular drug and vaccine delivery.
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