Journal
SMALL
Volume 9, Issue 3, Pages 446-456Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201201003
Keywords
graphene; hostguest; cyclodextrins; biomedical applications
Categories
Funding
- National Natural Science Foundation of China [21104059, 51173136, 51073121]
- Tongji university [2011032, 2011033]
- Shanghai Municipal Education Commission
- Shanghai Education Development Foundation
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A multi-component nanosystem based on graphene and comprising individual cyclodextrins at its surface is assembled, creating hybrid structures enabling new and important functionalities: optical imaging, drug storage, and cell targeting for medical diagnosis and treatment. These nanohybrids are part of a universal system of interchangeable units, capable of mutilple functionalities. The surface components, made of individual -cyclodextrin molecules, are the hosts for functional units, which may be used as imaging agents, for anti-cancer drug delivery, and as tumor-specific ligands. Specifically, individual -cyclodextrin (-CD), with a known capability to host various molecules, is considered a module unit that is assembled onto graphene nanosheet (GNS). The cyclodextrin-functionalized graphene nanosheet (GNS/-CD) enables hostguest chemistry between the nanohybrid and functional payloads. The structure, composition, and morphology of the graphene nanosheet hybrid have been investigated. The nanohybrid, GNS/-CD, is highly dispersive in various physiological solutions, reflecting the high biostability of cyclodextrin. Regarding the host capability, the nanohybrid is fully capable of selectively accommodating various biological and functional agents in a controlled fashion, including the antivirus drug amantadine, fluorescent dye [5(6)-carboxyfluorescein], and Arg-Gly-Asp (RGD) peptide-targeting ligands assisted by an adamantine linker. The loading ratio of 5(6)-carboxyfluorescein is as high as 110% with a drug concentration of 0.45 mg mL1. The cyclic RGD-functionalized nanohybrid exhibits remarkable targeting for HeLa cells.
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