Journal
SMALL
Volume 9, Issue 3, Pages 413-420Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201201849
Keywords
gold nanodots; galvanic replacement; strong fluorescence; cellular imaging
Categories
Funding
- National Nature Science Foundation of China [21174048, 30830108]
- 111 project [B06009]
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Fluorescent gold nanodots (GNDs) are an important kind of nanoprobes. Herein, the application of galvanic replacement for the preparation of fluorescent GNDs is reported. Using presynthesized and size-controlled Ag nanodots (Ag NDs) as templates, the as-prepared GNDs have strong fluorescence (quantum yields approximate to 10%) with high stability and surface bioactivity. The resultant GNDs show excellent photoluminescence properties with high photo-, time-, metal-, and pH-stability, which are attributed to the protective surface layer of glutathione (GSH) and the presence of Au(I)S complexes on the surface of the gold core. GSH, a naturally occurring and readily available tripeptide with carboxyl and amino functional groups, allows good dispersion of the as-prepared GNDs in aqueous solution and favorable biocompatibility. These advantages, combined with their small size, mean that the as-prepared GNDs have potential application in biological labeling, especially as a DNA probe for the specific detection of nucleic acids. In this study, the CAL-27 cells are used as a model to evaluate the fluorescence imaging of GNDs.
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