Journal
SMALL
Volume 9, Issue 2, Pages 178-186Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201202174
Keywords
artificial spores; cells; cell-in-shell; cytocompatibility; encapsulation
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Funding
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2012R1A3A2026403, 2012-0000908]
- Korea National University of Education
- National Research Foundation of Korea [2009-0083525, 2012R1A3A2026403] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Cells are encapsulated individually within thin and tough shells in a cytocompatible way, by mimicking the structure of bacterial endospores that survive under hostile conditions. The 3D cell-in-shell structurescoined as artificial spores'enable modulation and control over cellular metabolism, such as control of cell division, resistance to external stresses, and surface-functionalizability, providing a useful platform for applications, including cell-based sensors, cell therapy, regenerative medicine, as well as for fundamental studies on cellular metabolism at the single-cell level and cell-to-cell communications. This Concept focuses on chemical approaches to single-cell encapsulation with artificial shells for creating artificial spores, including cross-linked layer-by-layer assembly, bioinspired mineralization, and mussel-inspired polymerization. The current status and future prospects of this emerging field are also discussed.
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