Journal
SMALL
Volume 7, Issue 21, Pages 3087-3095Publisher
WILEY-BLACKWELL
DOI: 10.1002/smll.201101193
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Funding
- Pole de Recherche et d'Enseignement Superieur UniverSud Paris
- Region Ile-de-France
- CNRS
- CEA
- Ministry of Higher Education and Research
- Region Ile-de-France, France
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The ability of diamond nanoparticles (nanodiamonds, NDs) to deliver small interfering RNA (siRNA) into Ewing sarcoma cells is investigated with a view to the possibility of in-vivo anticancer nucleic-acid drug delivery. siRNA is adsorbed onto NDs that are coated with cationic polymer. Cell uptake of NDs is demonstrated by taking advantage of the NDs' intrinsic fluorescence from embedded color-center defects. Cell toxicity of these coated NDs is shown to be low. Consistent with the internalization efficacy, a specific inhibition of EWS/Fli-1 gene expression is shown at the mRNA and protein level by the ND-vectorized siRNA in a serum-containing medium.
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