Journal
SMALL
Volume 7, Issue 2, Pages 271-280Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201001459
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Funding
- National Nature Science Foundation of China [50823007, 50972154]
- National Basic Research Program of China [2010CB934000, 2009CB930304]
- National 863 High-Tech Program [2007AA03Z317]
- Science and Technology Commission of Shanghai [10430712800]
- CASKJCX [KJCX2-YW-M02, KJCX2-YW-210]
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The in vivo biodistribution and urinary excretion of spherical mesoporous silica nanoparticles (MSNs) are evaluated by tail-vein injection in ICR mice, and the effects of the particle size and PEGylation are investigated. The results indicate that both MSNs and PEGylated MSNs of different particle sizes (80-360 nm) distribute mainly in the liver and spleen, a minority of them in the lungs, and a few in the kidney and heart. The PEGylated MSNs of smaller particle size escape more easily from capture by liver, spleen, and lung tissues, possess longer blood-circulation lifetime, and are more slowly biodegraded and correspondingly have a lower excreted amount of degradation products in the urine. Neither MSNs nor PEGylated MSNs cause tissue toxicity after 1 month in vivo.
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