Journal
SMALL
Volume 6, Issue 15, Pages 1686-1692Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201000560
Keywords
cellular imaging; fluorescent probes; graphene oxide; nanomaterials
Categories
Funding
- National Natural Science Foundation [90913014, 10975179]
- Ministry of Science and Technology [2007CB936000]
- Shanghai Municipal Commission for Science and Technology [0952 nm04600, 08JC1422600]
- Ministry of Health [2009ZX10004-301]
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Graphene is an increasingly important nanomaterial that has shown great promise in the area of nanotechnology. In this study, fluorescein-functionalized graphene oxide (GO) is synthesized via a polyethylene glycol (PEG) bridge and us application in intracellular imaging is explored GO is an oxide form of graphene that provides an ideal platform to prepare graphene-based functional nanomaterials via chemical modification. The PEG bridge was Introduced to prevent GO-induced quenching of conjugated fluorescein. The fluorescein-PEG-GO conjugate thus prepared exhibits excellent pH-tunable fluorescent properties and, more significantly, can be efficiently taken up by cells and serve as a fluorescent nanoprobe for intracellular imaging.
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