Journal
SMALL
Volume 6, Issue 14, Pages 1558-1564Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201000453
Keywords
crosslinkers; drug delivery; layer-by-layer assembly; selective degradation; subcompartmentalized hydrogel capsules
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Funding
- Australian Research Council
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Subcompartmentalized hydro gel capsules (SHCs) with selectively degradable carriers and subunits are designed for potential applications in drug delivery and microencapsulated biocatalysis. Thiolated poly(methacrylic acid) and poly(N-vinyl pyrrolidone) are used to assemble 3-mu m-diameter carrier capsules and 300-nm-diameter subunits, independently stabilized by a diverse range of covalent linkages. This paper presents examples of SHCs with tens of subcompartments and their successful drug loading, as well as selective degradation of the SHC carrier and/or subunits in response to multiple chemical stimuli.
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