Journal
SMALL
Volume 6, Issue 17, Pages 1836-1852Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201000379
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Funding
- Australian Research Council
- Federation Fellowship
- NHMRC [487922]
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Polymeric materials formed via layer-by-layer (LbL) assembly have promise for use as drug delivery vehicles. These multilayered materials, both as capsules and thin films, can encapsulate a high payload of toxic or sensitive drugs, and can be readily engineered and functionalized with specific properties. This review highlights important and recent studies that advance the use of LbL-assembled materials as therapeutic devices. It also seeks to identify areas that require additional investigation for future development of the field. A variety of drug-loading methods and delivery routes are discussed. The biological barriers to successful delivery are identified, and possible solutions to these problems are discussed. Finally, state-of-the-art degradation and cargo release mechanisms are also presented.
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