Journal
SMALL
Volume 6, Issue 14, Pages 1550-1557Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201000262
Keywords
aptamers; bioassays; nanoparticles; proteins; Raman spectroscopy
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Funding
- Lawrence Livermore National Laboratory [URP-06-019]
- NSF [DMR-0097611]
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Despite recent improvements, the development of highly sensitive and selective assays for multiplexed protein detection remains a challenging goal in modern proteomics.([1]) Key factors for successful multiplexed protein assays are high specificity, sensitivity, reproducibility, and large signal-to-noise (SIN) ratios. Multiplexed assays are necessary when fast recognition of target analytes in complex mixtures is required.([2]) The majority of protein detection methods have relied thus far on antibody/antigen recognition strategies.([3]) While this approach has proven effective for detecting single proteins, antibody cross-reactivity significantly limits implementation of enzyme-linked immunosorbent assay (ELISA) analogues for multiplexed detection.([4])
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