Journal
SMALL
Volume 5, Issue 23, Pages 2722-2729Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.200900923
Keywords
cytotoxicity; intracellular localization; mesoporous silica; microparticles; spherical nanoparticles
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Funding
- National Nature Science Foundation of China [20633090, 50823007]
- National 863 High-Tech Program [2007AA03Z317]
- Shanghai Rising-Star Progrom [07QA14061]
- Shanghai Nano-Science Project [0852nm03900]
- CASKJCX [KJCX2-YW-M02, KJCX2-YW-210]
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This work evaluates the cytotoxicity of spherical mesoporous silica (MS) nano- and microparticles and investigates the effects of particle size, concentration, biodegradation products of MS, residual surfactant, and surfactant removal by extraction and calcination on the cytotoxicity. The results from the intracellular localization of spherical MS nano- and microparticles with different sizes reveal the mechanism for their cytotoxicity and that the smaller particles in nanoscale are more easily endocytosed and consequently located within lysosomes.
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