Journal
SLEEP MEDICINE REVIEWS
Volume 18, Issue 1, Pages 89-97Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.smrv.2013.04.003
Keywords
Sleep-wake cycle; Ghrelin; Orexin; Growth hormone; Leptin; Obesity
Categories
Funding
- CONACYT [133178]
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Several studies have shown that ghrelin administration promotes wakefulness in rodents, while in human males it induces sleep but has no effect in women. Ghrelin also plays an important role in metabolism and appetite regulation, and as described in this review may participate in the energy balance during sleep. In this review, we summarize some of the effects induced by ghrelin administration on the sleep wake cycle in relation to the effects of other hormones, such as growth hormone, leptin, and orexin. Finally we discuss the relationship between sleep deprivation, obesity and ghrelin secretion pattern. (C) 2013 Elsevier Ltd. All rights reserved.
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