Journal
THERANOSTICS
Volume 5, Issue 9, Pages 1030-1045Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.11642
Keywords
Cancer; Nanoparticles; Radiation therapy; Radiobiology; Radiosensitization; Photodynamic therapy
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Funding
- research fund of the ANR [P2N ANR-10-NANO-0009 PDTX]
- French Ligue Nationale Contre le Cancer
- French INCa (Institut National du Cancer) [2011-130]
- research fund of the INCa PDTX-Nano
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This review focuses on the radiosensitization strategies that use high-Z nanoparticles. It does not establish an exhaustive list of the works in this field but rather propose constructive criticisms pointing out critical factors that could improve the nano-radiation therapy. Whereas most reviews show the chemists and/or biologists points of view, the present analysis is also seen through the prism of the medical physicist. In particular, we described and evaluated the influence of X-rays energy spectra using a numerical analysis. We observed a lack of standardization in preclinical studies that could partially explain the low number of translation to clinical applications for this innovative therapeutic strategy. Pointing out the critical parameters of high-Z nanoparticles radiosensitization, this review is expected to contribute to a larger preclinical and clinical development.
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