Journal
THERANOSTICS
Volume 5, Issue 12, Pages 1444-1455Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.13398
Keywords
Photothermal therapy; nanoparticles; magnetic resonance imaging; tumor blood vessels
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Funding
- National Science Foundation of China (NSFC) [81201086, 81471655, 81301256]
- intramural research program, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
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In spite of rapidly increasing interest in the use of nanoparticle-mediated photothermal therapy (PTT) for treatment of different types of tumors, very little is known on early treatment-related changes in tumor response. Using graphene oxide (GO) as a model nanoparticle (NP), in this study, we tracked the changes in tumors after GO NP-mediated PTT by magnetic resonance imaging (MRI) and quantitatively identified MRI multiple parameters to assess the dynamic changes of MRI signal in tumor at different heating levels and duration. We found a time- and temperature-dependent dynamic change of the MRI signal intensity in intratumor microenvironment prior to any morphological change of tumor, mainly due to quick and effective eradication of tumor blood vessels. Based on the distribution of GO particles, we also demonstrated that NP-medited PTT caused heterogeneous thermal injury of tumor. Overall, these new findings provide not only a clinical-related method for non-invasive early tracking, identifying, and monitoring treatment response of NP-mediated PTT but also show a new vision for better understanding mechanisms of NP-mediated PTT.
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