Journal
SLEEP MEDICINE
Volume 9, Issue 3, Pages 317-319Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.sleep.2007.05.003
Keywords
REM sleep behavior disorder; REM sleep; 5-HT; SSRI; 5-HT(1A) partial agonist; dorsal raphe nucleus
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Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia defined by intermittent loss of electromyographic atonia during REM sleep with emergence of complex and vigorous behaviors. Although the efficacy of several agents for treating RBD has been reported, a rationale for medication has not been established and the exact pathophysiological mechanisms of RBD are uncertain. We encountered a patient with idiopathic RBD that dramatically improved with selective serotonin reuptake inhibitors (SSRIs) and deteriorated with a 5-HT(1A) partial agonist, tandospirone. We report on the effects of these serotonin-modulating agents, which yield clues to a possible pharmacological approach to RBD. (C) 2007 Elsevier B.V. All rights reserved.
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