Systemic inflammation in non-obese children with obstructive sleep apnea

Background: Obstructive sleep apnea (OSA) has been associated with increased systemic inflammatory responses that may contribute to an increased risk for end-organ morbidity. The changes in levels of pro-inflammatory cytokine IL-6, and the anti-inflammatory cytokine IL-10, both of which play a major role in atherogenesis, a major consequence of OSA, have not specifically been assessed in pediatric patients. Methods: Consecutive non-obese children (aged 4-9 years) who were polysomnographically diagnosed with OSA, and age-, gender-, ethnicity-, and BMI-matched control children underwent a blood draw the next morning after a sleep study and plasma samples were assayed for interleukins 6 (IL-6) and 10 (IL-10). These tests were repeated 4-6 months after tonsillectomy and adenoidectomy (T&A) in children with OSA. Results: IL-6 levels were higher and IL-10 plasma levels were lower in children with OSA and returned to control levels after T&A. Conclusions: Systemic inflammation is a constitutive component and consequence of OSA in many children, even in the absence of obesity, and is reversible upon treatment in most patients. (C) 2007 Elsevier B.V. All rights reserved.