Journal
STEM CELL RESEARCH & THERAPY
Volume 6, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s13287-015-0067-4
Keywords
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Funding
- NHMRC [628946, APP100581]
- Victorian Government's Operational Infrastructure Support program
- ARC Future Fellowship [FT110100199]
- Alzheimer's Australia fellowship
- Australian Research Council [FT110100199] Funding Source: Australian Research Council
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The beta-amyloid (A beta) peptide and the A beta-oligomer receptor, prion protein (PrP), both influence neurogenesis. Using in vitro murine neural stem cells (NSCs), we investigated whether A beta and PrP interact to modify neurogenesis. A beta imparted PrP-dependent changes on NSC self-renewal, with PrP-ablated and wild-type NSCs displaying increased and decreased cell growth, respectively. In contrast, differentiation of A beta-treated NSCs into mature cells was unaffected by PrP expression. Such marked PrP-dependent differences in NSC growth responses to A beta provides further evidence of biologically significant interactions between these two factors and an important new insight into regulation of NSC self-renewal in vivo.
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