Journal
STEM CELL RESEARCH & THERAPY
Volume 6, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13287-015-0232-9
Keywords
-
Funding
- Italian Multiple Sclerosis Foundation (FISM) [RG 2010/R/31]
- Italian Ministry of Health [GR08/7]
- European Research Council (ERC) [RG 260511-SEM_SEM]
- Evelyn Trust [RG 69865]
- Bascule Charitable Trust [RG 75149]
- Wellcome Trust
- MRC
- Gates Cambridge Trust
- IntraEuropean (IEF) Marie Curie Fellowship [RG 74074]
Ask authors/readers for more resources
Extracellular vesicles (EVs) are a heterogeneous population of naturally occurring secreted small vesicles, with distinct biophysical properties and different functions both in physiology and under pathological conditions. In recent years, a number of studies have demonstrated that EVs might hold remarkable potential in regenerative medicine by acting as therapeutically promising nanodrugs. Understanding their final impact on the biology of specific target cells as well as clarification of their overall therapeutic impact remains a matter of intense debate. Here we review the key principles of EVs in physiological and pathological conditions with a specific highlight on the most recently described mechanisms regulating some of the EV-mediated effects. First, we describe the current debates and the upcoming research on EVs as potential novel therapeutics in regenerative medicine, either as unmodified agents or as functionalized small carriers for targeted drug delivery. Moreover, we address a number of safety aspects and regulatory limitations related to the novel nature of EV-mediated therapeutic applications. Despite the emerging possibilities of EV treatments, these issues need to be overcome in order to allow their safe and successful application in future explorative clinical studies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available