Journal
SKIN PHARMACOLOGY AND PHYSIOLOGY
Volume 22, Issue 1, Pages 45-48Publisher
KARGER
DOI: 10.1159/000183924
Keywords
Bepotastine; Antihistamine; Keratinocyte; Cytokine/chemokine; CD54
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Bepotastine besilate is an antihistaminic drug of the second generation with superior clinical responses. In this study, we investigated whether bepotastine modulates the production of cytokines/chemokines and the expression of CD54 in human epidermal keratinocytes. The production of IL-1 alpha, CXCL10, and CCL17 and the expression of CD54 were significantly suppressed by the addition of bepotastine. Bepotastine exerts its antiallergic action on keratinocytes by suppressing the production of certain proinflammatory cytokines, both Th1 and Th2 chemokines, and possibly by inhibiting the expression of CD54. Copyright (C) 2008 S. Karger AG, Basel
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