Journal
SHOCK
Volume 38, Issue 3, Pages 227-242Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/SHK.0b013e318262c4b0
Keywords
LPS; tolerance; Toll-like receptor; monocytes; alternatively activated macrophages; T(H)1; Treg; T(H)17
Funding
- Fundacao de Amparo a Pesquisa do Estado Sao Paulo (FAPESP) [2006/58744-1]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [303635/2008-8]
- FAPESP [2008/07511-2]
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Since the definition of systemic inflammatory response syndrome/sepsis was originally proposed, a large amount of new information has been generated showing a much more complex scenario of inflammatory and counterinflammatory responses during sepsis. Moreover, some fundamental mechanisms of sensing and destroying invading microorganisms have been uncovered, which include the discovery of TLR4 as the lipopolysaccharide (LPS) gene, implications of innate immune cells as drivers of the adaptive response to infection, and the modulation of multiple accessory molecules that stimulate or inhibit monocyte/macrophage and lymphocyte interactions. The complexity of the infection/injury-induced immune response could be better appreciated with the application of genomics and proteomics studies, and LPS was a useful tool in many of these studies. In this review, we discuss aspects of bacterial recognition and induced cellular activation during sepsis. Because of the relevance of endotoxin (LPS) research in the field, we focus on LPS and host interactions as a clue to understand microorganisms sensing and cell signaling, then we discuss how this response is modulated in septic patients.
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