Journal
SEXUALLY TRANSMITTED DISEASES
Volume 35, Issue 9, Pages 791-796Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/OLQ.0b013e3181788301
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Funding
- NCATS NIH HHS [UL1 TR000448] Funding Source: Medline
- NCRR NIH HHS [5K12RR023249, KL2RR024994] Funding Source: Medline
- NICHD NIH HHS [K24 HD01298, K24 HD001298] Funding Source: Medline
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Background: Bacterial vaginosis (BV) is a common condition believed to be associated with sexually transmitted infection (STI) susceptibility. Most studies of BV and STIs have come from treatment-seeking or high-risk populations. This study examines the association between 5 viral STIs, human papilloma virus (HPV), HIV, herpes simplex viruses types I and 2 (HSV-1 and HSV-2), and Hepatitis C (HCV), and BV among women in the general US population. Methods: Data from the 2001 and 2003-2004 National Health and Nutrition Examination Surveys were combined. Crude and adjusted relative risks and 95% confidence intervals were estimated from logistic regression analyses for rare outcomes (<10%) and from Poisson regression with robust error variance for common outcomes. Complex survey design was taken into consideration using the survey functions in Stata. Results: Crude analyses found an association between BV and the prevalence of all 5 STIs. After adjustment for important confounders, only HSV-1 and HSV-2 were significantly associated with the presence of BV. Moreover, crude analyses stratified by race/ethnicity suggested that associations between BV and viral STIs may not be consistent across race/ethnicity subgroups. Conclusion: This population-based study found that BV was significantly associated with the prevalence of HSV-1, and HSV-2 and potentially associated with HIV and HPV. Given the frequency of BV in US women, small increases in STI susceptibility may have important impacts on STI transmission.
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