Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 196, Issue -, Pages 421-428Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2014.02.029
Keywords
Chemosensor; Hg(II); Ratiometric; Fluorescence; Sensor; Selective
Funding
- Basic Research Program of the National Research Foundation [2012R1A1B3000574]
- Korea Environmental Industry and Technology Institute [2012000540013]
- Korea Environmental Industry & Technology Institute (KEITI) [ARQ201202034003] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Korea Health Promotion Institute [1220210-1] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2012M3A9A8052645, 2013R1A2A1A01009184, 2008-0059996, 2009-0093927, 2012R1A1B3000574] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A fluorescent chemosensor (Pyr-Tyr) based on tyrosine showed highly selective and sensitive ratiometric response to Hg(II) among 14 metal ions in buffered aqueous solutions. The emission intensity ratio at 480 and 383 nm increased significantly from 0 to about 1.5 with the increase of Hg(II) concentrations (0-1 equiv.) and the ratiometric response to Hg(II) was not interfered by other metal ions such as Cu(II), Cd(II), and Ag(I). The detection limit of the chemo sensor for Hg(II) was calculated to be 12 +/- 1 nM (2.4 ppb). Pyr-Tyr exhibited ratiometric responses to Hg(II) in a wide range of pH values (pH 4.5-11.5) and the chemosensor was demonstrated to detect intracellular Hg(II) in HeLa cells. The binding mode of the chemosensor with Hg(II) was investigated by H-1 NMR titration and pH titration experiments, and ESI mass spectrometry. (C) 2014 Elsevier B.V. All rights reserved.
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