Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 202, Issue -, Pages 866-872Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2014.06.023
Keywords
Thermoplastic; Microfluidics; Polymer monolith; Biosensor; Immunosensor
Funding
- Canon U.S. Life Sciences, Inc.
- NIH [R01AI096215]
- DARPA [N66001-1-4003]
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A unique method for incorporating functional porous polymer monolith elements into thermoplastic microfluidic chips is described. Monolith elements are formed in a microfabricated mold, rather than within the microchannels, and chemically functionalized off chip before insertion into solvent-softened thermoplastic microchannels during chip assembly. Because monoliths may be trimmed prior to final placement, control of their size, shape, and uniformity is greatly improved over in situ photopolymerization methods. A characteristic trapezoidal profile facilitates rapid insertion and enables complete mechanical anchoring of the monolith periphery, eliminating the need for chemical attachment to the microchannel walls. Off-chip processing allows the parallel preparation of monoliths of differing compositions and surface chemistries in large batches. Multifunctional flow-through arrays of multiple monolith elements are demonstrated using this approach through the creation of a fluorescent immunosensor with integrated controls, and a microfluidic bubble separator comprising a combination of integrated hydrophobic and hydrophilic monolith elements. (C) 2014 Elsevier B.V. All rights reserved.
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