4.7 Article

New aliphatic and aromatic dialdehyde bridged turn-on probes for hypochlorite detection in biological samples based on bis(fluorescein)

Journal

SENSORS AND ACTUATORS B-CHEMICAL
Volume 202, Issue -, Pages 656-662

Publisher

ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2014.05.130

Keywords

Fluorescent probe; Dialdehyde; Hypochlorite; DFT computation; Bio-imaging

Funding

  1. National Natural Science Foundation of China [21272184, 21103137, 21143010, 11210057]
  2. Shaanxi Provincial Natural Science Fund Project [2012JQ2007]
  3. Northwest University Science Foundation for Postgraduate Students [YZZ12030, YZZ13042]
  4. Chinese National Innovation Experiment Program for University Students [201210697011]

Ask authors/readers for more resources

The design, synthesis and photo-physical properties of two novel dialdehyde bridged turn-on fluorescent probes with dual C=N moiety based on bis(fluorescein) for GO- detection with high selectivity and sensitivity were reported. The well-defined linear plots between 5.0 mu M and 500.0 mu M of OCl- make the probes especially suitable for the quantification of OCl-. The ring-opening progress was investigated both experimentally and computationally. Fluorescent imaging for OCl- in living MG-63 cells have also been successfully performed. (C) 2014 Elsevier B.V. All rights reserved.

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