A facile electrochemical sensor based on reduced graphene oxide and Au nanoplates modified glassy carbon electrode for simultaneous detection of ascorbic acid, dopamine and uric acid

facile Au nanoplates and reduced graphene oxide (RGO) modified glassy carbon electrode (GCE) was fabricated via a simple electrochemical method, denoted as Au/RGO/GCE. The Au/RGO/GCE electrode was used for the simultaneous detection of ascorbic acid (AA), dopamine (DA) and uric acid (UA). The modified electrodes fabricated by different methods presented different morphologies and performances for determination of AA, DA, and UA. Three well-defined voltammetric peaks along with remarkable increasing electrooxidation currents were obtained on the Au/RGO/GCE with needle-like Au nanoplates in differential pulse voltammetry (DPV) measurements. It was found that there are linear relationships between the peak currents and the concentrations in the range of 2.4 x 10(-4) to 1.5 x 10(-3) M (AA), 6.8 x 10(-6) to 4.1 x 10(-5) M (DA), and 8.8 x 10(-6) to 5.3 x 10(-5) M (UA), and the limits of simultaneous determination(based on S/N = 3) are 5.1 x 10(-5) M, 1.4 x 10(-6) M, and 1.8 x 10(-6)M for AA, DA and UA, respectively. Additionally, the Au/RGO/GCE electrode presented well anti-interference ability, stability and reproducibility. (C) 2014 Elsevier B. V. All rights reserved.