Application of a new ferrocene-derivative modified-graphene paste electrode for simultaneous determination of isoproterenol, acetaminophen and theophylline

A new ferrocene-derivative compound, 1-(4-bromobenzyl)-4-ferrocenyl-1H-[1,2,3]-triazole (1,4-BBFT), was synthesized and used to construct a modified-graphene paste electrode. Also, hydrophilic ionic liquid(n-hexyl-3-methylimidazolium hexafluoro phosphate) was used as a binder to prepare the modified electrode. The electro-oxidation of isoproterenol at the surface of the modified electrode was studied using cyclic voltammetry (CV), chronoamperometry (CHA), and square wave voltammetry (SWV). Under the optimized conditions, the square wave voltammetric peak current of isoproterenol increased linearly with isoproterenol concentration in the ranges of 6.0 x 10(-8) to 7.0 x 10(-4) mol L-1 and detection limit of 12.0nmol L-1 was obtained for isoproterenol. The diffusion coefficient and kinetic parameters (such as electron transfer coefficient and the heterogeneous rate constant) for isoproterenol oxidation were also determined. The prepared modified electrode exhibits a very good resolution between the voltammetric peaks of isoproterenol, acetaminophen and theophylline which makes it suitable for the detection of isoproterenol in the presence of acetaminophen and theophylline in real samples. (C) 2014 Elsevier B.V. All rights reserved.