Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 192, Issue -, Pages 150-156Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2013.10.097
Keywords
Fe-Ni layered double hydroxide; Hemin; Mimetic peroxidase; Electrochemical sensor
Funding
- National Natural Science Foundation of China [20805002, 21275009]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, MOE. China
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A novel mimetic peroxidase, layered double hydroxide (LDH)-hemin nanocomposite, was first prepared by immobilizing hemin between the nanosheets of Fe-Ni LDH obtained through hydrothermal method. It showed an improved peroxidase-like activity to H2O2 compared with hemin alone, which was proved by UV-Vis spectroscopy and electrochemical measurements. The electrochemical sensor based on Fe-Ni LDH-hemin nanocomposite exhibited a fast response to H2O2 with good linear range of 1-240 mu M, a detection limit of 0.3 mu M based on a signal-to-noise ratio of 3 and high selectivity. It performed better than the sensors based on HRP and hemin which were prepared in the same conditions. The high performance of the sensor made LDH-hemin nanocomposite a promising mimetic peroxidase to replace natural enzymes. (C) 2013 Elsevier B.V. All rights reserved.
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