Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 176, Issue -, Pages 660-666Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2012.09.016
Keywords
Ibuprofen; Potentiometric sensors; Pharmaceuticals; Cyclodextrins; Waters
Funding
- FCT, Fundacao para a Ciencia e Tecnologia [PTDC/ECM/103141/2008]
- Fundacao para a Ciencia e a Tecnologia [PEst-C/EQB/LA0006/2011]
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In this work, a potentiometric sensor for ibuprofen monitoring in pharmaceuticals and waters is described. The sensor development relied on comparative performance evaluation of membranes based on several commercial cyclodextrins. The optimum membrane comprised 1.2 wt.% alpha-cyclodextrin, 65.6 wt.% o-nitrophenyloctylether plasticizer, 42% mol (relative to the molar concentration of the ionophore) of tetradodecylammonium bromide and 32.8 wt.% PVC. A conductive polymeric resin coated with the membrane used as low impedance solid contact completed the sensor device. The sensor presented a constant sensitivity of -59.0 mV dec(-1) in the concentration range of 3.87 x 10(-6) to 10(-2) M, for samples with pH adjusted to 9. The response time was fast <15 s and reproducible (+/- 0.8 mV) with constant performance over more than 6 months. The practical limit of detection was of (3.34 +/- 0.03) x 10(-6) M ibuprofen. Sample analysis enabling accurate and reproducible results as well as the ability to be coupled to samples front-end conditioning procedures used in environmental analysis is also evidenced. (C) 2012 Elsevier B.V. All rights reserved.
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