Rhodamine hydrazone derivatives based selective fluorescent and colorimetric chemodosimeters for Hg2+ and selective colorimetric chemosensor for Cu2+

In this paper, we report new rhodamine hydrazone derivatives bearing multiple ether units or phenol group as selective fluorescent and calorimetric chemodosimeters for Hg2+ and a selective colorimetric chemosensor for Cu2+. Monomeric derivative 1 containing additional ether moieties and a dimeric system 2 displayed excellent fluorescence and calorimetric selectivity for Hg2+ in aqueous solution. 1 displayed much lower detection limit compared to 2 and both of these new hydrazone derivatives act as chemodosimeters for Hg2+. On the other hand, dimeric system 3 containing an additional phenol group showed a highly selective and reversible calorimetric change with Cu2+ in CH3CN-HEPES buffer. The detection limit was calculated as 0.15 mu M with the linear range of 280-800 nM. Finally, probe 1 was further applied to the cell-imaging of Hg2+ using HeLa cells. (C) 2013 Elsevier B.V. All rights reserved.