4.7 Article

A circuit design of a low-cost, portable and programmable electroporation device for biomedical applications

Journal

SENSORS AND ACTUATORS B-CHEMICAL
Volume 166, Issue -, Pages 292-300

Publisher

ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2012.02.065

Keywords

Electroporation; Low-cost; Programmable; Biomedical

Funding

  1. National Science Council, Taiwan, Republic of China [NSC 100-2221-E-260-007-, NSC 99-2221-E-260-004-, NSC 98-2221-E-260-024-MY3]
  2. National Chi Nan University, Taiwan, Republic of China [10011100]

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Electroporation for transdermal drug delivery or for non-invasive monitoring of patients could allow a new generation of medical devices to be developed for low-cost healthcare. The existing electroporation systems today are bulky, expensive or not fully programmable. Therefore, a compact, low-cost and programmable device was developed and evaluated. A circuit is described herein which provides a variety of adjustable high-voltage (2-300V) electric waveforms (pulsed and pulsed-biphasic) for electroporation. Evaluation showed that this device provides for precise regulation of the magnitude and waveform of a high-voltage over a wide range of impedance, important for in vivo/human use. Also, the device was evaluated in vitro to be capable of enhancing transdermal extraction of metabolites, like uric acid, for non-invasive monitoring and transdermal delivery of medications, like insulin, for non-invasive drug delivery. (C) 2012 Elsevier B.V. All rights reserved.

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